The Sweeping Antibody® is a recycling antibody that has been further engineered to bind to Fc receptor to enhance the cellular uptake of antibody-antigen complex. This allows antibody to not only bind to the target antigen in plasma but also enables antibody to eliminate or remove the antigen from plasma which cannot be achieved by conventional antibodies. Our first Sweeping Antibody® is, GYM329, is now being tested in clinical study, and we have multiple Sweeping Antibody® projects in the drug discovery stage.
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering
J Immunol. 2015 Oct 1;195(7):3198-205