The Sweeping Antibody® is a recycling antibody that was engineered further to bind to Fc receptors and enhance the cellular uptake of antibody-antigen complex. This allows the antibody to not only bind to target antigens in plasma but also eliminate or remove them. Our first Sweeping Antibody®, GYM329, is being tested in clinical studies, and we have multiple Sweeping Antibody® projects within the drug discovery stage.
Sweeping Antibody® is a registered trademark of Chugai Pharmaceutical Co., Ltd. (Tokyo, Japan)
Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering
J Immunol. 2015 Oct 1;195(7):3198-205