We work on drug discovery by combining our proprietary global top level antibody engineering and cyclic peptide technology and biological hypothesis of disease causing mechanism to solve the unmet medical needs.

Sweeping Antibody®

The Sweeping Antibody® is a recycling antibody that was engineered further to bind to Fc receptors and enhance the cellular uptake of antibody-antigen complex. This allows the antibody to not only bind to target antigens in plasma but also eliminate or remove them. Our first Sweeping Antibody®, GYM329, is being tested in clinical studies, and we have multiple Sweeping Antibody® projects within the drug discovery stage.

Sweeping Antibody® is a registered trademark of Chugai Pharmaceutical Co., Ltd. (Tokyo, Japan)

Reference Article:

Inhibitory FcγRIIb-Mediated Soluble Antigen Clearance from Plasma by a pH-Dependent Antigen-Binding Antibody and Its Enhancement by Fc Engineering

J Immunol. 2015 Oct 1;195(7):3198-205

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