Publications

Title: Humanization and Simultaneous Optimization of Monoclonal Antibody
Author: Taichi Kuramochi
Journal: Methods in Molecular Biology, 2019, vol. 1904, p. 213-230.


Title: Controlled conductivity at low pH in Protein L chromatography enables separation of bispecific and other antibody formats by their binding valency
Author: Chen Chen
Journal: mAbs, 2019, vol 11, p632-638.


Title: 生命機能に迫る分子化学 生命分子を真似る,飾る,超える (CSJ: 30)
Author: Tomoyuki Igawa
Publication: 化学同人, 2018, p. 204.


Title: 次世代抗体医薬の衝撃
Author: Tomoyuki Igawa
Journal: 実験医学, 2018, vol. 36, no. 11, p. 1820-1829.


Title: Long lasting neutralization of C5 by SKY59, a novel recycling antibody, is a potential therapy for complement-mediated diseases
Author: Taku Fukuzawa
Journal: Scientific Reports, 2017, vol. 7, no. 1080.


Title: Sweeping antibody as a novel therapeutic antibody modality capable of eliminating soluble antigens from circulation
Author: Tomoyuki Igawa
Journal: Immunological reviews, 2016, vol. 270, no. 1, p. 132-151.


Title: Improvement of pharmacokinetic properties of therapeutic antibodies by antibody engineering
Author: Kenta Haraya
Journal:  Drug Metabolism and Pharmacokinetics, 2019, vol. 34 no. 1, p. 25-41.


New factor VIII-function mimetic antibodies engineered from emicizumab for further improving the treatment of hemophilia A
Author: Yuri Teranishi
Conference: ISTH 2020


Drug discovery using recycling and sweeping antibody technology (Poster)
Author: Naoka Hironiwa
Conference: 2nd Antibody Engineering and Therapeutics Asia 2020


Drug discovery using bispecific and asymmetric antibody technology
Author: Yuri Teranishi
Conference: 2nd Drug Discovery Using Bispecific and Asymmetric Antibody Technology 2020


Drug discovery using recycling and sweeping antibody technology (Oral)
Author: Naoka Hironiwa
Conference: 2nd Antibody Engineering and Therapeutics Asia 2020


Anti-HPV16 E7 peptide MHC I antibody identification for T cell bispecifics by Rabbit single B cell cloning
Authors: Noriyuki Takahashi
Conference: 2nd Antibody Engineering and Therapeutics Asia 2020


New factor VIII function-mimetic bispecific antibodies engineered from emicizumab for further improving the treatment of hemophilia A
Author: Yuri Teranishi
Conference: 2nd Antibody engineering and therapeutics Asia 2020


Novel antibody engineering to improve therapeutic index of antibody targeting solid tumor
Author: Futa Mimoto
Conference: 7th Antibody Symposium 2020


New factor VIII function-mimetic bispecific antibodies engineered from emicizumab for further improving the treatment of hemophilia A
Author: Tomoyuki Igawa
Conference: 7th Antibody Symposium 2020


Cellular and analytical assays for PK engineering
Author: Lam Runyi Adeline
Conference: PepTalk 2019


Humanized anti-FIXa/FX bispecific antibody for the treatment of hemophilia A and beyond
Author: Yuri Teranishi
Conference: Antibody Engineering and Therapeutics Asia 2019


Drug discovery driven by antibody engineering technologies
Author: Tomoyuki Igawa
Conference: 1st Antibody Engineering & Therapeutics Asia 2019


Drug Discovery driven by antibody engineering technologies
Author: Tomoyuki Igawa
Conference: 第12回 ミッドウィンターセミナー2019


Lead antibody identification against membrane protein targets using Rabbit single B cell cloning technology
Author: Noriyuki Takahashi
Conference: Discovery on Target 2019


Isoelectric point engineering to enhance the potency of therapeutic antibody
Author: Taichi Kuramochi
Conference: Antibody Engineering & Therapeutics 2019


Sweeping antibodytechnology to enhance the potency of therapeutic antibody
Author: Taichi Kuramochi
Conference: 6th Antibody Symposium 2019


Novel antibody engineering to improve therapeutic index of antibody targeting solid tumor
Author: Futa Mimoto
Conference: Antibody Engineering and Therapeutics Conference 2019


Anti-GPRC5D/CD3 bispecific T cell-redirecting antibody for the treatment of multiple myeloma
Author: Tatsushi Kodama
Conference: 6th Antibody Symposium 2019


Anti-HPV16 E7 peptide MHC I antibody identification for T cell bispecifics by Rabbit single B cell cloning
Author: Noriyuki Takahashi
Conference: Antibody Engineering and Therapeutics 2018


次世代医薬等基盤技術
Author: Tomoyuki Igawa
Conference: JSTCDRS ライフサイエンス 臨床医学分野 2018


Bispecific antibody as next generation antibody therapeutics Emicizumab (anti-FIXa/FX bispecific antibody), ERY 974 (anti-GPC3/CD3) bispecific antibody
Author: Tomoyuki Igawa
Conference: Gordon Conference、Poster 2018


Antibody engineering technologies to solve unmet medical needs
Author: Tomoyuki Igawa
Conference: Gordon Conference、Oral 2018


Discovery and development of therapeutic bispecific antibodies
Author: Tomoyuki Igawa
Conference: EpiVax Seminar 2018


Discovery and development of therapeutic bispecific antibodies
Author: Tomoyuki Igawa
Conference: 日本医療学会年会 2018


Novel Cell-based assays for PK screening during antibody optimisation
Author: Lam Runyi Adeline
Conference: Antibody Engineering & Therapeutics 2018


Tricks to enhance bispecific antibody purification by using Protein L chromatography
Author: Yuichiro Shimizu
Conference: Peptalk 2018


Tricks to enhance bispecific antibody purification by using Protein L chromatography
Author: Yuichiro Shimizu
Conference: Peptalk 2018


Application of Biacore in pH dependent Ab screening
Author: Gan Siok Wan
Conference: DIPIA 2018


Efficient B cell cloning and antibody engineering platform for rare Ab generation
Author: Feng Shu
Conference: Peptalk 2018


Isoelectric point engineering to enhance the potency of an antibody with pH-dependent antigen binding
Author: Taichi Kuramochi
Conference: 1st Antibody Engineering & Therapeutics 2017


Rabbit single B-cell cloning platform in Chugai
Author: Noriyuki Takahashi
Conference: 1st Antibody Engineering and Therapeutics 2017


Continuous innovative drug discovery utilizing antibody engineering technology
Author: Tomoyuki Igawa
Conference: BioJapan 2017


Drug discovery of antibody therapeutics and research activities in Chugai Pharmabody Research
Author: Tomoyuki Igawa
Conference: 日本大使館主催JCC科学技術講演会 2017


Optimization strategy to generate antibody with high solubility and low viscosity for SC formulation
Author: Masaru Muraoka
Conference: 13th PEGS Boston 2017


Modeling and simulation analysis of a novel engineered therapeutic antibody with PH-dependent binding to target antigen
Author: Kenta Haraya
Conference: 11th International ISSX Meeting 2016


Lead Identification function: Powerful antibody discovery platform with B-cell cloning and high throughput screening to identify rarest and most valuable lead antibody
Author: Yoshinao Ruike
Conference: 3rd Antibody Symposium 2015


Antibody drug discovery research to create new value
Author: Meiri Kawazoe
Conference: 第32回JASSセミナー 2015


Advanced characterization of biotherapeutics
Author: Meiri Kawazoe
Conference: 3rd Antibody Symposium 2015


Optimal formulation design of antibody drugs for subcutaneous delivery to provide patients with great value
Author: Meiri Kawazoe
Conference: 3rd Antibody Symposium 2015


Lead optimization function: “Antibody Crafting” with high through-put comprehensive mutagenesis approach
Author: Feng Shu
Conference: 3rd Antibody Symposium 2015


Protein Production function: step-by-step solutions for different bottlenecks of gram-scale antibody production to accelerate drug discovery processes
Author: Yuichiro Shimizu
Conference: 3rd Antibody Symposium 2015


Antibody expression and purification platform for early-stage R&D
Author: Yuichiro Shimizu
Conference: BioPharmaAsia convention 2014


Generation of an asymmetric bispecific IgG antibody mimicking the function of FVIII cofactor activity for the treatment of hemophilia A
Author: Zenjiro Sampei
Conference: 10th PEGS


Chugai’s proprietary antibody engineering technologies
Author: Junichi Nezu
Conference: 1st Taiwan-Japan Joint Conference on the Development of Therapeutic Antibodies 2014


Utilization of empower network for superior research environment
Author: Meiri Kawazoe
Conference: 1st Singapore separation User Forum 2014


PK optimization and preclinical PK of novel bispecific antibody against FIXa and X for the treatment of hemophilia A
Author: Kenta Haraya
Conference: Second Annual PK/PD of Multi-Domain Proteins conference, PEGS 2014


Engineered Antibody to Sweep Antigen by pH-Dependent Antigen Binding and Increased FcRn Binding
Author: Tatsuhiko Tachibana
Conference: 19th North American Regional ISSX Meeting and 29th JSSX Annual Meeting 2014


Solution based kinetics & affinity assay for Ab/Ag interaction: Assay development using Octet quantitation assay
Author: Gan Siok Wan
Conference: 1st Pall-forteBio Antibody Workshop 2014


Clarification of cell culture supernatant using BioOptimal MF-SL in early-stage R&D
Author: Yuichiro Shimizu
Conference: 17th Planova workshop 2014


SMART-Ig; novel antibody recycling technology by engineering endosomal antigen dissociation
Author: Junichi Nezu
Conference: Drug Discovery World Asia 2013


Antibody drug discovery process in CPR based on recycling & sweeping antibody technology
Author: Junichi Nezu
Conference: Antibody Engineering Asia 2013


Engineered monoclonal antibody with novel antigen-sweeping activity in vivo
Author: Tatsuhiko Tachibana
Conference: 2nd ADME BioTx 2nd Workshop 2013


Generation of an asymmetric bispecific IgG antibody that restores factor VIII hemostatic activity in a hemophilia A model
Author: Zenjiro Sampei
Conference: 2nd Antibody Symposium 2013


Virtual clinical trial-prediction of interindividual variability in pharmacokinetics of CYP2C8 substrates
Author: Kenta Haraya
Conference: JSSX 2013


Antibody drug discovery process in CPR based on recycling & sweeping antibody technology
Author: Junichi Nezu
Conference: 1st Antibody Symposium 2012